After stabilization in anaphylaxis, what is the role of corticosteroids?

In cases of anaphylaxis, the immediate first-line treatment involves the administration of adrenaline, which works rapidly to counteract the severe allergic reaction. Following initial stabilization with adrenaline and other supportive measures, corticosteroids play a crucial role in the management of anaphylaxis by helping to reduce inflammation and prevent recurrence of symptoms after the immediate effects of adrenaline wear off.

Corticosteroids are particularly effective for their anti-inflammatory properties and can help mitigate the delayed hyperreactive response that may occur after the acute phase of anaphylaxis. Although they are not the first-line treatment or a substitute for adrenaline, their use after stabilization can be important in managing ongoing allergic responses, particularly in patients who may experience a biphasic reaction.

This makes their role critical in refractory cases where a patient may continue to present symptoms or where there is a risk of a second wave of anaphylaxis. Additionally, the use of corticosteroids in these situations has been supported by guidelines to help ensure that patients receive comprehensive care following an episode of anaphylaxis.