What interval is recommended for administering IM adrenaline during a refractory anaphylactic response?

In the context of a refractory anaphylactic response, administering intramuscular (IM) adrenaline at intervals of every 5 minutes is recommended. This timing allows for the adequate management of severe anaphylaxis, where symptoms can re-emerge even after initial treatment.

The rationale for this interval is based on the pharmacokinetics of adrenaline, which needs to be administered promptly and efficiently to counteract anaphylactic symptoms that can escalate rapidly. A 5-minute interval ensures that there is a sufficient frequency of dose delivery to maintain effective blood levels of the medication, particularly since the symptoms of anaphylaxis can progress quickly and unpredictably.

Other time intervals, like 3 minutes, may lead to excessive or unnecessary dosing, while longer intervals such as 10 or 15 minutes might not provide the prompt intervention needed during a critical situation. Thus, administering IM adrenaline every 5 minutes strikes the right balance for both efficacy and safety during a refractory response.