What is the most common early sign of anaphylaxis?

The most common early sign of anaphylaxis is skin or mucosal changes. In many cases, these changes manifest as urticaria (hives), angioedema (swelling, particularly around the eyes and lips), or generalized flushing. These symptoms typically appear soon after exposure to an allergen and represent the body's immediate hypersensitivity response.

Recognizing these early signs is crucial for timely intervention, as they often precede more severe symptoms such as respiratory distress or cardiovascular collapse. These later signs indicate a progression in the severity of the reaction, leading to potential airway compromise or shock, necessitating urgent medical attention. Hence, identifying and responding to skin or mucosal changes is a key initial step in the management of anaphylaxis.