Which of the following signs and symptoms are indicative of opiate poisoning?

The signs and symptoms indicative of opiate poisoning prominently include pinpoint pupils and respiratory depression. When a person is experiencing opiate poisoning, the central nervous system effects result in constricted pupils, often referred to as "miosis." This is a classic hallmark of opiate use and toxicity.

Respiratory depression is another critical sign of opiate poisoning. Opiates affect the brain's respiratory centers, leading to a decrease in the rate and depth of breathing, which can be life-threatening. Monitoring respiratory function in suspected cases of opioid overdose is a central part of the assessment and management of the patient.

While increased heart rate, rash with sweating, fever, and nausea may be associated with other conditions or substances, they are not characteristic signs of opiate poisoning. Understanding these specific symptoms aids in the rapid recognition and appropriate intervention in potential cases of opiate overdose, which may include administering naloxone to reverse the effects of the opiates.